人工臓器
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
ペプロマイシンマイクロカプセルの製剤化と微小化学塞栓術への応用に関する基礎的研究
加藤 哲郎森 久阿部 良悦餌取 和美海野 勝男後藤 昭雄室田 英行原田 昌興新藤 雅章千葉 隆一
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1982 年 11 巻 1 号 p. 213-216

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Peplomycin (PEP), a new derivative of bleomycin, was prepared in a form of ethylcellulose microcapsules (PEP-m.c.) based on a modified phase separation method. PEP-m.c. had a mean particle size of 235μm with a rough surface and could be infused through a 18 G needle. Bioassay proved that the drug activity was not affected by the microencapsulation process employed. In vitro assay showed that PEP-m.c. has a slow release property, but the release rate in the early phase was considerably high, suggesting a need of modifications in the dosage form.
When PEP-m.c. were infused into the renal artery of the rabbits, a high drug activity was sustained in the kidney as compared with the nonencapsulated PEP infusion. Circulating blood level of PEP also decreased significantly in the PEP-m.c. group as compared with that in the control. Cytotoxic effects on the kidney tissues were markedly enhanced in the PEP-m.c. group as compared with those in other experimental groups treated with nonencapsulated PEP, placebo microcapsules or combination of the both.
The results indicate that selective arterial infusion of PEP-m.c. provides an intensive topical antitumor effects through a function of microinfarction and prolonged drug action.
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