抄録
Two types of modules, in which planer blood channels and sorbent layers were stacked alternately, were constructed for ex vivo experiments of plasma separation and perfusion. Type I comprised five channels and six sorbent layers, both 200mm long and 50mm wide. Four of the sorbent layers, respectively between two channels, were 10mm thick, and the other two, between a channel and an end plate were 5mm thick. The total packing volume of sorbent was 500ml. The inner surface of a channel was porous polymeric membrane, Nudepore Membrane Filter, supported by a pair of 35% perforated metal sheets from the outside. The total effective area of the membrane was 0.035m2. In this kind of modules, the blood plasma is, along the channels, infiltrated through the membrane into the sorbent layers and, near by the outlets, returned to the channels: in other words, separation, perfusion and return of plasma are successively practiced from the upper reaches to the lower. Type II had the almost same constructions to those of Type I, but the sorbent layers were bisected perpendicularly to the blood stream direction. This is equivalent to the series connected two modules of half length of Type I. The experiments were carried out on creatininized dogs. The tested membrane pore size were 0.8 and 2μm. The set thickness of the channels were 0.15 and 0.2mm. In every case, the blood compatibility was sufficient. The plasma separation efficiency was examined by the ratio of creatinine removal from the blood stream. The 2μm pored membrane showed poor permeability. The highest removal ratio, obtained with the 0.8μm pored membrane, was nearly 30%.
