Rapid Dialysis

-Based upon Consideration on Acid-Base Balance-

Abstract

As acid-base balance should be taken into consideration for realizing a rapid and comfortable therapy, we have measured permeability of HCO₃^- and CH₃COO^- across membranes of dialyzers and found that PMMA membrane dialyzer, “B2-300” has significantly lower permeability for these two solutes than a cellulosic dialyzer with same surface area despite of its comparable permeability for urea and creatinine. It seems that such reduced permeability of “B2-300” prevents rapid loss of HCO₃^- into and inflow of CH₃COO^- from dialysate containing CH₃COO^- and that it thus contributes to a decrease in dialysis-related symptoms observed in the comparative clinical evaluations.