Abstract
It has been reported that sodium acetate has a depressant action on the cardiovascualr system. In this study hemodynamic change during five hours hemodialysis was invasively evaluated by a method of left and right heart catheterization in four patients, especially on ventricular contractility, total peripheral resistance index (TPRI) and their interactions with blood acetate. We adopted max dp/dt and max dp/dt/p as indices of the contractility.
At the onset of hypotension the contractility was depressed with concomittant falls in cardiac index (C. I.), mean blood pressure (BP) and TPRI. After rapid infusion the depressed contractility was improved with marked rises in C. I. and BP. Even during asymptomatic periods the contractility might be depressed or enhauncedo Blood sample for the determination of acetate level was obtained from four sites such as shunt, left ventricle, pulmonary artery and right atrium. The level in shunt was closely identical with those in left ventricle as well as in pulmonary artery, however, in right atrium, about a half of the level.
Each contractility parameter and TPRI were statistically compared with acetate levels in all sites, respectively. However, no better corelations were found in all.
