Abstract
A computerized coma monitor (CCM), analyzing standard deviations of EEG parameters, such as probability function, peak point histogram, integrated histogram and frequency distribution histogram, and zero cross counts, has been developed for evaluating level of hepatic or metabolic encephalopathy.
The analyzed values are displayed on the monitor scope in graphic or digital mode at regular intervals. The dispaly on the scope is automatically printed out at regular interval if desired. hepatectomized pigs and the patients suffering from acute hepatic failure with satisfactory results. The standard deviation of frequency distribution increased and number of zero cross counts decreased gradually, with the passage of time, in tottaly hepatectom mized pig. Theses trends reversed by charcoal plasma perfusion. This improvement of brain wave was confirmed by molar ratio of plasma aminoacids. Similar relationship between the trends of theses parameters and the clinical coma grade of the patients with acute hepatic failure, treated by plasma exchange, was observed.
CCM has a great advantage to evaluate brain wave mathematically and it is useful for monitoring hepatic and metabolic encephalopathy.
