Abstract
The hybrid artificial pancreas attached to the systemic circulation, containing 10000 xenogeneic hamster islets, restored normoglycemia in 4 out of 6 totally pancreatectomized dogs. However, none of 4 dogs achieved to normoglycemia, when this device was attached to the portal circulation. The device attached to the portal circulation, containing 14000 islets, was able to restore normoglycemia in 4 out of 5 dogs. Plasma insulin levels after attachment to the systemic circulation were higher than those to the portal circulation. While, there was no significant difference in pattern of plasma glucose disposal.
