Abstract
In order to study the relationship between the adsorption characteristics of IgG and the induction of the effector function, we measured O2 production from macrophages stimulated with antibody and immune complexes adsorbed to various polymer surfaces. Our findings suggest that activation of the Fc receptor-mediated function of macrophages requires, on the one hand, optimal conformational change and orientation of IgG and immune complexes adsorbed to the polymer surface and, on the other hand, the bridging of IgG molecules by multivalent agents.
