Experimental Application of Polyvinyl Alcohol-silica composite for Artificial Vessels

Abstract

Small artificial vessels, coated with PVA-SiO₂ composite, were replaced at the parts of canine abdominal aorta for one and a half year. Patency rates were as follows: control 2/7; PVA-SiO₂ coating 4/7; PVA-SiO₂+heparin coating 8/12. The inner surfaces of these samples were observed with light microscopy and scan electronmicroscopy. Intima formation was thinner on the PVA-SiO₂ composite surfaces than on the control surfaces. Heparin functions as local anticoagulant and PVA-SiO₂ composite can control intima formation.