Abstract
Ascending aorta replacement under extracorporeal circulation is often associated with uncontrollable bleeding through the prosthetic wall in spite of the preclotting with fresh blood. Instead of the preclotting with blood, vascular prostheses were pretreated with fibrin glue and clinically utilized. Fibrin glue consists of 2 components; highly concentrated fibrinogen as the substrate and thrombin, calcium and aprotinin as the thromboplastic substances. The high concentrated fibrinogen solution was firstly spreaded, then, the solution of thromboplastic agents was applied to the outer surface of prostheses. After a few minutes a thin fibrin film developed. The pressure tolerance test was performed and leakage through the pretreated prostheses was not seen under the pressure of 300mmHg.
In three patients undergoing ascending aorta replacement under extracorporeal circulation the pretreated Dacron grafts were implanted and there was no blood loss across the prostheses. It is concluded that the fibrin glue is available for the vascular surgery.
