Abstract
The purpose of plasmapheresis is to remove antigens, antibodies, immune complexes, complement and coagulation factors in the treatment of renal transplant rejection. However, unnecessary removal of immune regulatory factors may simultaneously occur and stimulate immune reaction to result in rebound after plasmapheresis.
Suppressor and growth soluble factors (kinds of lymphokins), well known as regulators in immune responses. In vitro study demonstrates adsorbability of 65 materials to suppressor and growth soluble factors. Of these, Amberlite XAD-2 shows large capacity of adsorbability to growth soluble factors, but not plasma proteins. Adsorbability of Amberlite XAD-2 to growth soluble factors which is contained in suppressor soluble factors is confirmed by the experimental result that suppressive effect is sharply incresased from 19.2 to 59.0% after 10 minutes incubation and to 73.0% after 30 minutes incubation. Irradiation to lymphocytes by Ultraviolet (UV) ray has strong capacity of immune suppression, and we studied suppressive effect of UV with irradiation time, wave length and its intensity.
