血漿灌流免疫複合体吸着システムの基礎的研究

山崎 善弥; 藤森 義蔵; 高浜 龍彦; 和田 達雄; 宮本 昭正; 風間 睦美; 吉沢 久嘉; 高橋 幸喜; 荻田 忠厚; 井上 昇; 山脇 直邦; 稲垣 健二; 津田 信明

doi:10.11392/jsao1972.12.311

Plasma perfusion system for immunoadsorption of immune complex

Z. YAMAZAKI, Y. FUJIMORI, T. TAKAHAMA, T. WADW, T. MIYAMOTO, M. KAZAMA, H. YOSHIZAWA, T. TAKAHASHI, T. OGITA, N. INOUE, N. YAMAWAKI, K. INAGAKI, S. TSUDA

Author information

Z. YAMAZAKI
University of Tokyo
Y. FUJIMORI
University of Tokyo
T. TAKAHAMA
University of Tokyo
T. WADW
[in Japanese]
T. MIYAMOTO
[in Japanese]
M. KAZAMA
[in Japanese]
H. YOSHIZAWA
University of Tokyo
T. TAKAHASHI
University of Tokyo
T. OGITA
[in Japanese]
N. INOUE
[in Japanese]
N. YAMAWAKI
University of Tokyo
K. INAGAKI
University of Tokyo
S. TSUDA
University of Tokyo

Keywords: immunoadsorbent immune complex, rheumatoid factor, coagulation factor, plasma perfusion

JOURNAL FREE ACCESS

1983 Volume 12 Issue 1 Pages 311-314

DOI https://doi.org/10.11392/jsao1972.12.311

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Abstract

A new immunoadsorbent (I-02), adsorbing rheumatoid factor and immune complex, has been developed. Batchwise adsorption studies revealed that I-02 is more efficient than Protein A- Sepharose CL4B. During ex vivo I-02 plasma perfusion in the dogs, coagulation and fibrinolysis factors were almost constant. Blood biochemical parameters were within normal limits. Platelets aggregation value is almost constant. I-02 plasma perfusion was carried out in the patient with chronic rheumatic arthritis with satisfactory results.

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