Abstract
The pharmacokinetics of fosfomycin was studied after intravenous drip infusion in 5 patients undergoing hemodialysis. All were chronic hemodialysis patients. Mean fosfomycin clearance by hemodialysis was 124.3±22.2ml/min. Pharmacokinetic parameters were derived using a 1-compartment model. During hemodialysis, the mean distribution volume was 10.16±1.66 1; the mean total body clearance was 5.91±0.75 1/hour; and the mean serum half life was 1.21±0.29 hour. Our results showed that fosfomycin is well dialyzed and that it is entirely eliminated by the artificial kidney on chronic hemodialysis patients.
