Abstract
As slow released anticancer drug 5-Fu polylactic acid composite (F-PLA needle) was newly prepared. In the present studies, the properties of this preparation were clarified, and its anticancer effect was investigated. The findings are as follows. 1) The release speed of 5-Fu from the F-PLA needle was found to be slower than from the S-Fu-polyglycolic acid composite (F-PGA needle). 2) When two F-PLA needles were implanted in each tumors of rats which received subcutaneous transplants of AH 130, tumor proliferation was markedly inhibited with an inhibition rate of 94.4% at 12 days after implantation. Based on these results, it was found that the F-PLA needle was longer-acting than F-PGA needle and had marked anticancer effect.
