Experimental evaluation of extracorporeal circulation by membrane oxygenator in combination with centrifugal pump—Comparison with bubble oxygenator and roller pump

Abstract

Twenty four mongrel dogs were devided into 4 groups: Group I (N=6) underwent ECC for 2hr by bubble oxygenator (Bu) with roller pump (Ro), Group II (N=4) by Bu with centrifugal pump (Ce), Group III (N=6) by membrane oxygenator (Me) with Ro, and Group IV (N=8) by Me with Ce. These 4 groups were studied in the aspect of cardiovascular effects, platelet function, platelet index and function, whole blood aggregation, and the change of the vasoactive prostanoids. These conclusions were obtained. 1) Significant initial drop of platelet count at the onset of ECC was observed in Group I, II, III, but less in Group IV. 2) Preservation of platelet count in Group IV was better than other 3 groups. 3) Serum free hemoglobin was less in amount in Group IV than Group II and III (not statistically), but less statistically than Group I at the time of ECC 60min and 120min. 4) In the aspect of whole blood aggregation and 6 keto PGF_1α/TXB₂ ratio, easy thrombus formation was inhibited in Group IV to some extent.