GLYCEMIC CONTROL IN DIABETICS WITH CLOSED-LOOP SUBCUTANEOUS INSULIN INFUSION ALGORITHM

Abstract

For long-term clinical application of the wearable artificial endocrine pancreas, closed-loop subcutaneous insulin infusion algorithm has been developed from simulation study on subcutaneous insulin absorption kinetics. With this algorithm, glycemic levels were controlled without hyperglycemia nor hypoglycemia after oral glucose loads to pancreatectomized dogs or after meal loads to insulin-dependent diabetics. These data indicated feasibility of long-term glycemic control in diabetics with closed-loop subcutaneous insulin infusion by the wearable artificial endocrine pancreas.