人工心肺使用体外循環における補体活性化の抑制の試み ―FUT-175を用いた実験的検討―

宮本 裕治; 広瀬 一; 松田 暉; 中埜 粛; 白倉 良太; 中田 精三; 笹子 佳門; 西垣 恭一; 高見 宏; 川島 康生; 北村 肇; 永木 和義

doi:10.11392/jsao1972.14.1536

Complement activation during experimental cardiopulmonary bypass and inhibitory effect of FUT-175

Y. MIYAMOTO, H. HIROSE, H. MATSUDA, S. NAJANO, Y. SASAKO, K. NISHIGAKI, H. TAKAMI, Y. KAWASHIMA, [in Japanese], [in Japanese], H. KITAMURA, K. NAGAKI

Author information

Y. MIYAMOTO
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
H. HIROSE
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
H. MATSUDA
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
S. NAJANO
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
Y. SASAKO
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
K. NISHIGAKI
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
H. TAKAMI
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
Y. KAWASHIMA
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
[in Japanese]
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
[in Japanese]
First Department of-Surgery Osaka University Medical Scool Fukushima-ku
H. KITAMURA
The Center for Adult Diseases
K. NAGAKI
The Center for Adult Diseases

Keywords: complement acivation, anaphylatoxin, extracorporeal circulation, complement inhibitor, FUT-175

JOURNAL FREE ACCESS

1985 Volume 14 Issue 3 Pages 1536-1539

DOI https://doi.org/10.11392/jsao1972.14.1536

Details

Abstract

Complement activation during cardiopulmonary bypass was evaluated utilizing model circuit and classical pathway was found to be more activated compared to alternative pathway. In addition, it was indicated that this activation was strongly inhibited by FUT-175, new synthetic complement inhibitor.

Corresponding author

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