Abstract
To investigate regional oerebral blood flow (CBF) of oerebral aortex following circulatory arrest with reperfusian, 15 mandrel dogs were subjected to cardiopulmonary bypass(CPB) using a pulsatile pump. Flow rate of perfusion was prescribed to 100 ml/kg/mm during the experiment. CBF was surveyed by means of hydrogen clearance method. CBF at normothermic perfusion using a pulsatile pump was not decreased compared with CBF before CPB, and reduced to about 38% of CHF before circulatory arrest (esophageal temperature 20°C). CBF following circulatory arrest with reperfusion (36°C) has improved to that of normothermic perfusion before circulatory arrest. CBF immediately after reperfusion was markedly increased cranpered with CBF before circulatory arrest (about 300%), in spite of same esophageal temperature, flow rate of perfusion, and arterial pressure. This fact suggests that CBF immediately after reperfusicn increases because of progressive vasodilatation during circulatory arrest, but more precise studies of metabolism, histology or cerbral circulation are required.
