Abstract
The effect of prostaglandin E1 on the activation of platelet during cardiopulmonary bypass: Platelet activation during the first 60 min of cardiopulmonary bypass(CPB) was studied in 13 cases by measuring platelet count (P-C), platelet factor 4(PF4), β -thromboglobulin(βTG) and thromboxane B2. In group I (control), P-C were reduced to 72% of the initial values of CPB, and PF4, STG were increased to 210%, 209%, respectively. In group II and III, receiving 50 and 100ng/kg/min of prostaglandin E1 during CPB, P-C remained in the initial values. The increase of PF4 was less than in group I. Thromboxane B2 showed no changes in each groups. Prostaglandin E1 proved to prevent the reduction of P-C and release of PF4 during CPB.
