Abstract
The ion transport phenomenon in multi ion system across a charged membrane was studied by the theory basing upon the Donnan equilibrium and Nernst-Planck equation and examined in vitro. Then, this theory was applied to the analysis of ion transport on hemodialysis. Ion permeability coefficient rate (P. C. R.), the index of ion transpot coefficient across a charged membrane, showed good agreement between the results obtained from the therapy and those from in vitro studies. The theoretical analysiss of the ion transport across a charged hemodialysis membrane clarified that in positive charged membrane, the excretion of HPO42-, HCO3- and the entrance of CH3COO- were increased using acetate dialysate, and the excretion of HPO42- and the entrance of HCO3- were increased using bicarbonate dialysate. HPO42- excretion was also stimulated by adding the positive charged substances to dialysate. These results indicate that it is possible to predict the ion transport across a charged membrane theoretically, and the charged membrane may be useful to correct the electrolite disturbance effectively on hemodialysis therapy.
