Abstract
The mechanism of electrolyte transport through dialysis membranes should be clarified to improve inorganic phosphate removal from patients on long-term hemodialysis. Permeability to inorganic phosphate of regenerated cellulose(RC) and polymethyimethacrylate (PMMA) membranes was determined with aqueous radioisotope (32P)-labeled disodium hydrogenphosphate at varying inorganic phosphate concentrations. We measured permeability to inorganic phosphate in bovine serum and compared with the permeability in aqueous disodium hydrogenphosphate. Zeta potential of RC and PMMA membranes was measured by the streaming potential method. Inorganic phosphate concentrations ranging from 3.33 to 66.6mEq/l don't affect the permeability to inorganic phosphate which increases significantly with inorganic phosphate concentration at concentraions from 66.6 to 100mEq/l and is insensitive to the inorganic phosphate concentration at a concentration of >100mEq/l. Permeability to inorganic phosphate in bovine serum is higher than that in aqueous solution.
