CHARACTERISTICS OF HEAT TREATED COLLAGEN MATRIX

Abstract

We investigated the characteristics of heat treated collagen matrix under various conditions in the presence of water, and the biocompatibility of these collagen matrix implanted in rats and mice. As a result, when collagen matrix was treated with high temperature, mechanical strength and protease resistance of heat treated collagen matrix was inferior to those of non-treated collagen matrix, and the contractibility abruptly increaseed with the increase of treated temperature. In impalnted experiment in rats, non-treated collagen matrix was extremely low in the filtration of cells and was observed encapsulation, whereas heat treated collagen matrix were remarkable observed the infiltration of cells and were not observed encapsulation.