DEVELOPMENT OF DEVICE MADE OF SHAPE MEMORY POLYMER FOR CLOSURE OF DUCTUS ARTERIOSUS

Abstract

We developed a new transvenous technique for closure of patent ductus arteriosus (PDA). Prototype device for closure of PDA was made of shape memory polymer. The artificial great arteries model with “ductus arteriosus” was used for in vitro evaluation of the device. The device was inserted into “ductus artriosus” easily by guiding wire and pushing catheter. The introduction of hot water (50°C) through the catheter resulted in expanding of shape of the device. The device stayed in the “ductus arteriosus” without any support. The increased “aortic” pressure and decreased shunt flow were simultaneously observed. The prototype technique developed here promises clinical application.