A NEW THERAPY FOR GASTRIC ULCER -IN VIVO SYUDIES-

Abstract

Gastric ulcers in DM rats were treated with our newly devised combined drug, “G. T. XllI”. Gastric ulcer were induced with acetic acid solution to DM rats, which were induced with Streptozotosin. 3 days after, the all rats were gastrotomied to confirm ulcer formation. Then G. T. XII sol was directly injected to the ulcers (treated group, 8 rats). Only gastrotomy was given to non-treated group(6 rats). The healing process of the ulcers were macroscopically and historogically obserbed for three to 14 days. Macroscopically and histologically, the treated ulcers showed well organized healing process within a short term. These data suggest that topical injection of G. T. XIII promotes ulcer healing.