1990 Volume 19 Issue 3 Pages 1353-1356
To evaluate anticoagulant effect of protease inhibitors (Gabexate Mesilate, Nafamostat Mesilate) and Cepharanthin, the external jugular veins in mongrel dogs were replaced with Sauvage EXS Dacron grafts (I. D. 5mm). Immediately after replacement, the drugs were administered continiously through the posterior auricular veins. Three hours after replacement, the grafts were removed and examined macro-and microscopically. Experimental data suggest that protease inhibitor and Cepharanthin can decrease early thrombus formation significantly on smallcaliber prosthesis in the venous system (p<0.05). Specifically, it is worthy of attention that the combination use of Cepharanthin and Nafamostat Mesilate completely reduces very early thrombus formation without any bleeding tendency.
