Abstract
We developed a new type of adsorbent, PC-2, preparing from cross-linked agarose(SepharoseCL-4B) and hexamethylenediisocyanate. The beads are water swollen cross-linked gels and have the mean diameterof 55 micron in wet state. PC-2 can specifically remove beta-2-microglobul in, anti-AchR Ab, anti-nuclear Ab, anti-ds-DNA Ab, immune complex, IgG-RF. Thus, we sould enable to use PC-2 clinically for CRF, myasthenia gravis, rheumatoid arithritis or other autoimmune diseases. In this report, we also evaluated bio-compatibility and adsorption mechanism of PC-2.
