AUTOMATIC MEASUREMENT OF WHOLE BLOOD Xa ACTIVATED COAGULATION TIME AS A BED SIDE MONITORING METHOD FOR LOW MOLECULAR WEIGHT HEPARIN

Abstract

Automatic measurement of whole blood Xa activated coagulation time (XCT) was developed for the bed side monitor of low molecular weight heparin (LMWH) during hemodialysis (HD). Following the bolus injection of lOaXaU/kgxHD hour LMWH, plasma aXa, APTT and XCT measured by manual and automatic methods showed peak values at 1 hour after start of HD, followed by their gradual decreases. Although plasma Xa correlated significantly with APTT and two methods measuring XCT, the correlation coefficient and slopes of regression line were higher in the latter two methods than the former. Automatically measured XCT also reflected the changes in aXa more precisely than XCT by manual methods. These results indicate that automatically measured XCT is not only a simple and a rapid but also a precise method as a bed side monitor for LMWH.