Abstract
We compared the biocompatibility among three modified cel-lulose membranes, diethylaminoethyl cellulose (HE), cationic synthetic polymer mask-ing cellulose (BT), and the polyetyleneglycol chains grafting cellulose (PC), in the patients on long-term hemodialysis (HD). Leukocyte count at 15 min of HD decreased by 480 of pre-HD in HE, 30% in BT and 28% in PC, respectively, and no significant differance was observed in the reduction among those membranes. The change in platelet count remained within 100 of pre-HD values througtout HD. Arterial C3a levels elevated to 4573 ±1437 (HE), 694 ±328 (BT), and 660 ±210 ng/ml (PC) at 15 min, respectively, then HE showed the strongest complement activation. Granulocyte elastase increased significantly during HD, and the increasing rate was higher in BT than that in HE or PC. β-TG also increased markedly in all membranes, however no differance was noted in its increasing rates. These results indicate that PC is as-sumed to have the best biocompatibility (among three membranes) from the point of view in less activation of complement and granulocyte.
