Abstract
Comparative study of eliminatiug effects of uremic inhibitors on hematopoiesis was performed between two modules of dialyzers, e. g. cuprophane and EVAL membrane in 6 maintenance hemodialysis patients. Inhibitory effects on hematopoiesis were evaluated by counting the colony forming unit of erythroid (CFU-E) derived colonies using fetal mouse liver cells at suboptimal EPO level about 13 mU/ml, in which pre- and post-dialysis plasma were added in the cases of using each membranes. The number of CFU-E derived colonies by adding normal (control) plasma sample into CFU-E culture medium was 69.1 colonies/103, on the other hand, the number of them by adding pre-dialysis plasma sample was 63.3 colonies/103. And the number of CFU-E derived colony by adding post-dialysis plasma was greater than the number of colony by adding pre-dialysis plasma sample. Consequently, there could be a lot of inhibitory factors on hematopoiesis in dialysis plasma. But there is not a significant difference about a recovery of CFU-E derived colony growth between cuprophane and EVAL membrane. In this study, we failed to confirm no significant difference about recovering in CFU-E derived colony growth by adding pre- and post-dialysis plasma between both of membranes.
