Transit of Humoral Vasoactive Mediators in Intervention of Cardiopulmonary Bypass

—The effect of hemofiltration during the extracorporeal circulation—

Abstract

During a cardiopulmonary bypass(CPB), alternation of various vasoactive mediators is predicted and appea-red to paticipate in changes of systemic vascular resisance(SVR). In this study we measured serum levels of intrin-sic catecholamine(norepinephrine and epinephrine), angiotensin2, eicosanoid (thranboxane A2 and prostacyclin) and endothelia and had a regression analysis with SVR during and after the CPB. The serum levels of catecholamines and endothelin increased significantly during and after the CPB and the level of thromboxane A2 increased only du-ring the CPB. However, the change of angiotensin 2 was not observed. Only the level of noradrenalin revealed sign-ificant correlation with the SVR(r=0.64 after the CPB r=0.6 at protamine infusion and r=0.58 at ICU admission, p<0.05-0.01) and was considered to bean important influential factor toward the SVR.