Abstract
We have developed a biocompatible and high capacity adsorbent with using poly-hydroxyethyl methacrylate (Poly-HEMA) coated porous anion-exchange resin for the treatment of hyperbilirubinemia, In order to improve the biocompatibility of the adsorbent and prevent the release of microparticles from the porous resin, the resin beads were coated with hydrophilic poly-HEMA. With increasing the amounts of the coating, the adsorption of Plasma proteins was markedly reduced, In the in vitro study the coated adsorbent exhibited an excellent adsorptive property for bilirubin and bile acid. For clinical application, the plasma perfusion column, Medisorba BL which contains 300ml of the coated resin beads, sterilized by auto-claving has been developed. In the clinical evaluation, the bilirubin adsorption capacity of this column was estimated to be more than 51 0f treated plasma volume, Medisorba BL was highly effective and useful for the removal of bilirubin in the clinical treatment of hyperbilirubinemia.
