CLINICAL APPLICATION OF WEARABLE ARTIFICIAL ENDOCRINE PANCREAS WITH FERROCENE-MEDIATED NEEDLE-TYPE GLUCOSE SENSOR COVERED WITH NEWLY DESIGNED BIOCOMPATIBLE MEMBRANE

Abstract

To prepare the long-life and stable glucose sensor, we developed the ferrocene-mediated needle-type glucose sensor covered with newly designed biocompatible membrane, 2-methacryloyloxyethyl phosphorylcholine -co-n-butyl methacrylate (MPC-co-BMA) membrane. In this membrane, the hydrophilic phosphorylcholine chains were grafted on the hydrophobic polymer surface. 1. The subcutaneous tissue glucose concentrations could be monitored precisely for 7 days without any in vivo calibrations, and for 14 days by introducing in vivo calibrations in healthy volunteers. 2. This sensor applied to ambulatory diabetic patients for glycemic control with wearable artificial endocrine pancreas. When operating wearable artificial endocrine pancreas, physiological glycemic control was obtained by exchanging the sensor for 4 days.
We therefore conclude that this sensor is stable and reliable, as compared to any other glucose sensors we developed.