Abstract

Comparison study of complete artificial circulation for liver on cardiogenic shock: pulsatile or nonpulsatile? The weaning rate of mechanical circuratoly support on cardiogenic shock has increased, However, survival rate was not satisfactory, because of multiple oregan failure (MOF). The purpose of this study is to estimate the effects of pulsatile and nonpulsatile artificial circulation, to liver microcirculation and function. Cardiogenic shock was made by ligation of left anterior descending branch in pig. As right ventriculer assist device, nonpulsatile pump (Nikkiso HPM-15) was applied. Left ventricule device was supported by nonpulsatile pump (Nikkiso HPM-15) {NP group} or pulsatile pump (Zeon Medical). Both groups drived with equivalent meen aortic pressure for 3 hours. We measured the hepatic artery blood flow, potal vein blood flow and liver regional blood flow. As for metabolic data, GOT, GPT, arterial blood ketone body ratio (AKBR) and lactate/pimbic acid (L/P) were evaluated. The hepatic artery blood flow and potal vein blood flow were no differences between the both groups. However, in the P group, they showed more normal value than that of NP group. The regional blood flow of liver and AKBR, L/P showed significant improvements in P group compared with NP group. These findings suggest that pulsatile circulation may be beneficial for microcirculation of liver.