Abstract
We developed a novel cardio-pulmonary bypass (CPB) system with independent regulators for the bypass flow and the circulating blood volume. We put a blood reservoir chamber beside the main blood stream line of the pump. It was connected to the blood stream line via a branched line of the venous drainage tube. Using a roller pump attached to this branched line, we regulated the blood reserving volume, which inversely correlated with the blood circulating volume during CPB. We regulated the blood flow using the other roller pump attached to the main blood stream line. Through in vitro experiment using a special air trapping filter (Auto Vent SV Blood FilterTM), we elucidated that the air bubbles in the drainage tube could be completely eliminated. In clinical trials of 113 CPB cases, we encountered no significant complications. In all of these cases, we could regulate the blood flow and the circulating blood volume independently and safely. In conclusion, our novel CPB system was excellent in regulating the circulatory parameters and conditions precisely during CPB. Moreover, it could provide the possibility of the automatic regulation for CPB management.
