Abstract
Result of Verotoxinl, 2 absorption test of PMX Fiber Cellulose fiber with polymyxin B showed dose response absorption of endotoxin in vitro. Based on this result, we applied two PMX columns to endotoxemic patients. Hemoperfusions using single PMX columns were applied to 13 patients 18 times. Of these patients, hemoperfusions were applied twice to five individuals. Nine patients were treatedwith two sequential PMX columns (double PMX columns). The multiple organ failure (MOF) scores of both groups were very similar. There was no significant difference in the reduction of serum endotoxin level between single PMX column application and the use of double PMX columns. However, the survival rate of patiens treated with double PMX columns was significantly higher than that of the single PMX column application group. Our clinical trial showed the advantage of double PMX column application. PMX fiber was mixed with verotoxin 1 and 2(VT 1, 2) solution derived from E coli (O 157). PMX fiber did not absorb VT 1 and 2 for 120 minutes.
