In 12 patients with chronic renal failure and without obvious signs of congestive heart failure, cardiac functions and blood volume were analyzed immediately before and after hemodialysis. Investigations were performed through dye dilution method using external arterio-venous shunt. The patients were divided into two groups. One group was consisted of 6 patients socially rehabilitated and the other group was of 6 patients non-rehabilitated. An increase of cardiac output was resulted from hemodialysis in social rehabilitation group, whereas a slight decrease on cardiac output was caused in non-rehabilitation group. There were no significant differences in a decrease of total blood volume, body weightloss and a fall of arterial pressure following dialysis between two groups. In non-social rehabilitation group, cardiac output, stroke volume and arterial pressure were higher than those in rehabilitation group before hemodialysis. It was concluded that the change of cardiac output following hemodialysis was affected mainly not by dialysis technique but rather by predialysis condition of patient.