Study of direct hemoperfusion by activated charcoal microcapsule

Abstract

A new type of capsulated activated charcoal (AC) for direct hemoperf usion was investigated.
AC has some difficulties when used for direct hemoperfusion, i, e., release of AC powder, damages to cell elements of blood, platelet adhesion, platelet aggregation and so on. To conquer these difficulties, AC was processed as follows. (1) Powdered AC was shaped in beads, and (2) these beads were double-encapsulated by normal gelatin and modified gelatin produced for clinical use as plasma expander. Glutalaldehyde was used as across-linking agent. This modified gelatin coated AC microcapsule (MGAC) could overcome many weakpoints of uncoated AC without any reduction of its efficiency. 600ml MGA C column has very high efficiency compared to any other dialyser. This is really a success of clinically aveilable AC microcapsule.