Abstract
The purpose of this study was to evaluate the efficiency of oral administration of activated charcoal to the uremic patient.
Surface of activated charcoal was treated with konjacmannan (KAC); the main component of ‘konnyaku’, popular article of food in Japan. KAC-1 and 2 containes charcoal 17% and 95% in weight respectively.
KAC was administered via a jejumum catherer to uremic dogs induced by ligation of bilateral ureters: KAC-1 25g×2/day (Group 1), KAC-2 25g×2 and 4/day (Group 2 and 3) and none (control group).
Creatinine levels for experimental dogs were lower than that of control and at fifth day of operation, the former was about 70% of the latter. But difference was not significant among three groups each other.
This study suggested that oral administration of KAC might support hemodialysis therapy to a certain degree.
