This is part of comprehensive study on immobilization of urokinase (UK) [1, 2, 4]. In this study, UK was immobilized on two kinds of nylon tube surface: nylon-6 and nylon-11, using our newly devised technique and the antithrombogenicity of the materials was studied with clinical application.
The UK-immobilized materials were clinically applied in 70 cases as surgical drains or as intravascular catheters. Silicone coated tubes were used in 35 cases as controls.
Patency of the tubes was defined as follows: (+); patent for the duration of the clinical use, (±); patent for 48 hours or more and (-); obstructed within 48 hours after surgery.
Among 70 of the UK-immobilized materials, 67 were (+), only three were (±). As for controls, only one showed (+), 8 were (±) and 26 were (-).
Our newly devised UK-immobilized nylon tube proved to be an adequate antithrombogenic material.
