Abstract
Immobilization of some enzymes for medical use on surface of plastic tube or film has been studied by means of radiation polymerization at low temperatures. Glucose oxidase and glucose peroxidase could be immobilized inside polyvinyl chloride tube using glass-forming monomers as carrier. Double coating technique was used in this process to give the adhesiveness between polyvinyl chloride and coated membrane including enzymes. Urokinase was immobilized effectively on polyethylene film. In this case polyethylene film was preliminarily grafted by irradiation with other monomers to improve the affinity with monomer and polymer membrane. The film comprising urokinase showed anti-thrombogenecity to some degree.
