In artificial organ connected with blood vessel for long term, the connecting method and the selection of material is very important problem. In our artificial heart study, the cannulae has been inserted to right and left atrium, pulmonary artery and d. aorta and ligated with suture. However, It became necessary to change thee connected method with prolongation of animal's surviving time, because the ligated suture gradually cut into vessel wall and began to loose their fastening force for the acnnulae. As a connecting method, use of artificial blood vessel is thought to be one of the best method. But, it is generally said that thrombus formation will be accelerated at the boundary between foreign materials, especially between smooth surface and rough surface.
In this study, the thrombus formation at the boundary between PVC paste or Avcothane as the smooth surface and expanded polytetrafluoroethylene as the rough surface was investigated. EPTFE is easily connected with PVC paste or Avcothane by dipping method. Artificial heart cannula composed from these materials was sutured at pulmonary artery and d. aorta, and artificial heart was pumped during from few days to three months. At the boundary line, pseud-intima and smooth surface could co-existed stably.
It became clear that the composite of smooth surface and rough surface can be utilized for various artificial organs by appropriate selection of materials.
