体外循環時における凝固能, 血小板との関係

抄録

Fourty patients who underwent open heart Surgery for heart disease received transfusion of 20units of platelet concentrated (prepared from their own blood taken by the use of Haemonetics model 30) after peripheral circulation was adequately improved.
Determination were made of the platelet count and the adhensiveness and aggregation of platelets before operation, at termination of extracorporeal circulation, after the administration of protamin and also after transfusion of PC.
The results indicated that the platelet count was lowest at termination of extracorporeal circulation and returned to the postoperative level after infusion of PC. Similarly, the adhensiveness and aggregation of platelet were found lowest at termination of extracorporeal circulation and returned to almost preoperative levels after protamine dose and also after infusion of PC.
In the past, heparinization during extracorporeal circulation has been done on an empirical basis. Activated coagulation time by hemochron is useful method of monitoring heparin therapy during extra corporeal circulation.
To evaluate ACT., 27 consecutive open heart Surgery performed.
Mean ACT of heparinized blood was 397±110 second. and mean ACT after protamine was 129±23 second.