抄録
To investigate influence of electric charge on thrombus formation on the luminal surface of the prosthesis, a vascular prosthesis which made of electroconductive materials was placed in the inferior vena cava of the dogs. A large amount of coagulation was formed on the positive-charged luminal surface, whereas few amount coagulation was formed on the negative-charged surface. And the non-charged that is electroconductive surface showed similarly anticoagulant effect.
In examining with SEM the process of neointima formation in implanted vascular prosthesis, it appeared that constructed fibrin matrix layer prevented futher adhesion of blood cells and the platelets adhered and covered only the incomplete areas of fibrin matrix formation. These phenomena of forming fibrin matrix seem to reduce the positive charge and may even make luminal surface negative.
In vitro experiments using platelet-rich plasma, it was shown that only a few platelets with slight deformation were adhered to the negative-charged surface but a number of deformed platelets with stretched pseudopods and fusing themselves were attached to the positive-charged surface.
These results indicate that electroconductivity is an important factor of anticoagulant effect on blood conduit.
