Comparison of anti-hyaluronidase activities and sugar compositions of extracts from four edible species of Nostoc (cyanobacteria)

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The edible species of Nostoc are unique cyanobacteria because they can grow in some extreme environments, and some of these species are rare. Anti-hyaluronidase activity and sugar composition of the extracts were compared among five edible Nostoc strains which were cultured using 180 liter large scale reactor. The IC₅₀ against hyaluronidase of the extracts of Nostoc sphaericum, Nostoc flagelliforme and Nostoc verrucosum were 14.4, 46.5 and 56.2 μg mL ^-1, respectively. These anti-hyaluronidase activities were higher than disodium cromoglycate which is known as an anti-allergic drug and used as a positive control substance. The ratio of glucuronic acid in constituent sugar of N. sphaericum extract was 13.3%, it was the highest among the five strains tested. The extract of N. sphaericum had the highest yield and highest anti-hyaluronidase activity when compared with the other four Nostoc strains.