抄録
As the representative strain capable of showing the benign type leprosy, brown mice of (C57BL/6×CF1) F10 were used for this experiment. These mice were infected subcutaneously or intraperitoneally with murine leprosy bacilli and then superinfected subcutaneously with INAH-resistant bacilli 6 weeks later. To examine the influence of primary infection on the leproma development of superinfection, the drug (INAH) administration was started on the 2nd day of superinfection and continued for 10 weeks. The results were judged by palpation of positive lesions at the challenged site.
A remarkable suppression of the leproma development of superinfection was observed in treated mice. This observation appears to indicate that the benign type lepromas of primary infection, though inhibited in their progress by INAH, conferred immunity to the superinfection.
On the other hand, it seemed that immunity did not develop when the mice were treated with INAH before establishment of the characteristic lesions of mouse leprosy.
