Abstract
In the experimental shigella infections in the monkies, four animals (two groups, 2 monkies each) were infected with young cultures of Shigella flexneri type 2a or 2b.
In the first group, each animal were administered directly into the stomach, 500-1000×108/kg of live organisms. Pretreatment was performed with one of the animals (5g·ENaHCO3was administered orally after one day starvation). Another was not pretreated.
In the second group, each animal were operated upon, and 50-200×108/kg of live organisms were injected directly into the intestinal tract. One of the animals was injected into the proximal duodenum, and another into the proximal caecum. The clinical and pathological observations were made.
The results were as follows:
1) In the comparatively young monky weighing 1.2 kg which was not pretreated, symptoms of acute bacillary dysentery were observed and the symptoms were closely resembled to those of acute bacillary dysentery which were seen in human beings.
2) The pretreated monky of the first group and two monkies of the second group excreted normal stool or had diarrhoea (watery, caddy and bloody stool).
One of these three monkies excreted dysentery bacilli. In any case, all three animals showed extremely severe general symptoms as compared with one which was not pretreated. These animals were followed by the death within 3-7 days after the infection.
Pathological changes were observed with various organs including brain, stomach, intestinal tract and liver etc.
The details will be published later.
