1962 Volume 17 Issue 8 Pages 706-710
In the previous reports, it was repeatedly confirmed that M. phlei coated with the fat extracted fromguinea pigs gave the severe changes on the guinea pigs, while the water-suspended one showed no visiblelesions.
This paper presents that the similar phenomena are observed also in the rabbits and mice.
Both animals were inoculated intracerebrally and intraperitoneally with M. phlei coated with fatextracted from each animal.
Rabbits inoculated intracerebrally with fat-coated bacilli revealed the wide-spread meningeal abscess, and intraperitoneally showed severe adhesions in abdominal cavity with numerous abscesses and tubercles insome organs.
In the case of mice, the similar findings were observed, but various organs had no tubercle.
M. phlei was detectable for a longer time in both animals inoculated with fat-coated bacilli, whilenone or few in the water-suspended one.
Furthermore, the attenuated strain of INH-resistant tubercle bacilli was injected on the guinea pigsunder the condition of coating with liquid paraffin. The results of this trial showed the virulence of thisstrain was preserved by mean of Oil-coating same as M. phlei.
