Experimental Shigella Infections in mice

III. On the Transferability of Drug Resistance from a Resistant Strain of Shigella to a Sensitive Strain of Escherichia in vivo

Abstract

The authors isolated the three (SA·SM·CM)-resistant strains of Escherichia coli from the feces of mice inoculated orally with a resistant strain of Shigella flexneri 3a and two (SA·CM)-resistant strains of unidentified gram-negative, lactose-non-fermenting rods.
Drug resistance of the former 3 resistant strains was transferable in vitro to a drug-sensitive (SA·SM·CM) strain which was resistant to tetracycline; however, the drug resistance of the latter two strains were not transferable
cf.: SA=sulfisoxazole, SM=streptomycin, CM=chloramphenicol.