Abstract
It is considered that the cellular factor plays a great role in the immunity of experimental typhoid. In order to clearify this cellular factor, we have tried to examine relations between the metabolic changes of host cells and immune process. The activities of several kinds of enzymes of the mouse peritoneal cells. were quantified during 4 weeks after vaccination with such vaccine as attenuated living vaccines, chrome-treated. killed vaccines or endotoxin. The results obtained were following.
(1) Acid phosphatase activity of the peritoneal cells was increased after injection of those vaccines. Especially, 11 Rx living vaccine, which was known to give good immunity to the hosts, could greatly increase the enzyme activity of those cells.
(2) Although the lysozyme activity was increased after inoculation of both living vaccines, 11 Rx. living vaccine appeared to be more effective to increase the activity than Jena living vaccine which was known to give poor immunity to the hosts. The injection with chrome-treated killed vaccines or endotoxin, which were known not to give cellular immunity to the hosts, decreased the activity of lysozyme of the host cells.
(3) Cathepsin activity was slightly increased after injections of those various kinds of vaccines.
(4) After inoculation of 11 Rx living vaccine, β-gluculonidase activity and succinic dehydrogenase activity were examined and were found that β-gluculonidase activity was usualy low in comparison with that of the normal controls and succinic dehydrogenase activity was variable.
