Studies on the Prophylaxis against Habu Snake (Trimeresurus flavoviridis) Bite by Snake Venom Toxoid

1. On the side reaction and antibody level after the immunization of the toxoid

Abstract

Dihydrothioctic acid inactivated Habu snake venom toxoids were injected subcutaneously into people of Amami Islands.
2771 persons of Amami Islands received shots of 0.5ml. of dihydrothioctic acid inactivated Habu venom toxoids at the interval of two weeks which contained 2.5mg. of snake venom and dihydrothioctic acids.
Main local reactions were slight swelling and pains by pressure of the locus of injection continued several days. Most people who had received shots were able to work without fever or other general symptoms.
Although a rise in the antivenine titer occurred, the level of circulating antibody which were produced as a results of active immunizations was lower than that of animals.