抄録
Plasma testosterone concentration (PTC) was estimated in normal adults and in cases of various endocrine diseases, by using the competitive protein binding method described by Mayes and Nugent (1968) with slight modifications.
PTC of normal female and male adults under the basal conditions were 0.30±0.15 (SD) and 6.23±1.69 (SD)ng/ml, respectively, which had already been reported elsewhere (Japan. J. Urol., 61: 1088, 1970 and 62: 708, 1971).
PTC from the spermatic vein revealed a variety, namely roughly 40 to 200 times as high as the levels from peripheral male plasma. There was no significant differences in the mean PTC between normal and paraplegic men, though the testicular sizes were considerably smaller in the latters. A lowered PTC following surgical stress recovered to the preoperative levels in several weeks in major surgery, and in several days in moderate one where plasma LH increased as early as half an hour after operative incision, and then decreased below the preoperative levels on the second day of surgery. PTC was well reduced by injections of progestins in cases of advanced renal tumors and in male precocious puberty. PTC was lower than normal in cases of male Cushing's syndrome, delayed puberty in male teenagers, eunuchoidism and various hypogonadism. PTC higher than the normal was found in the cases of congenital adrenal hyperplasia with 21-hydroxylase deficiency, virilizing adrenal adenoma, and polycystic ovary syndrome. As a result of the stimulation test with HCG 3, 000iu+PMS 3,000 iu (daily) of three or four successive days injections, PTC incresed to a slight extent in Klinefelter's syndrome and did not sufficiently in hypogonadotropic hypogonadism. Upon infusion of LH-RH, a decapeptide, both plasma LH/FSH and PTC increased in a case of cryptoorchidism; only LH/FSH did in Steinert's syndrome and neither did in hypogonadotropic hypogonadism.
